Corosolic acid (CRA) is a pentacyclic triterpenoid isolated from Lagerstroemia speciosa. The aim of the present study was to determine whether CRA reduces cardiac remodelling following myocardial infarction (MI) and to elucidate the underlying mechanisms. C57BL/6J mice were randomly divided into control (PBS‑treated) or CRA‑treated groups. After 14 days of pre‑treatment, the mice were subjected to either sham surgery or permanent ligation of the left anterior descending artery. Following surgery, all animals were treated with PBS or CRA (10 or 20 mg/kg/day) for 4 weeks. After 4 weeks, echocardiographic, haemodynamic, gravimetric, histological and biochemical analyses were conducted. The results revealed that, upon MI, mice with CRA treatment exhibited decreased mortality rates, improved ventricular function and attenuated cardiac fibrosis compared with those in control mice. Furthermore, CRA treatment resulted in reduced oxidative stress, inflammation and apoptosis, as well as inhibited the transforming growth factor β1/Smad signalling pathway activation in cardiac tissue. In vitro studies further indicated that inhibition of AMP‑activated protein kinase α (AMPKα) reversed the protective effect of CRA. In conclusion, the study revealed that CRA attenuated MI‑induced cardiac fibrosis and dysfunction through modulation of inflammation and oxidative stress associated with AMPKα.
Corosolic acid (CRA) is a triterpenoid compound discovered in numerous medicinal herbs, particularly in Lagerstroemia speciosa L. (also known as Banaba). CRA initially attracted much attention for its anti-diabetic function while further studies demonstrated that CRA has more functions, including antitumour and anti-atherosclerotic properties . Previous studies have confirmed that CRA inhibits acute inflammation by regulating IRAK-1 phosphorylation via an NF-κB-independent pathway in macrophages . In addition, in endothelial dysfunction, CRA protects mitochondrial function by regulating Drp1 phosphorylation (Ser637) in an AMPK-dependent manner, which contributes to inhibiting Nox2 oxidase signalling and suppressing NLRP3 inflammasome activation . However, to the best of our knowledge, the effects of CRA on post-MI remodelling have not been reported to date.
The above information about corosolic acid is from the Internet and literature for reference only.
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