research of corosolic acid for blood sugar and diabetes

corosolic acid is a substance extracted from the herb Lagerstroemia speciosa and has been reported to have biological activities, as discovered in in vitro and experimental animal studies, particularly due to its influence on blood sugar. Thus, it may have an influence on diabetes. It is found in many plants, particularly banaba, but also in almond hulls, Weigela subsessilis, Perilla frutescens, Campsis grandiflora and other herbs. It is a pentacyclic triterpene and inhibits glycogen phosphorylases.

Corosolic acid research – Blood sugar and diabetes
Effect of corosolic acid on postchallenge plasma glucose levels.
Diabetes Research Clinical Practice. 2006. Department of Diabetes and Clinical Nutrition, Kyoto University, Kyoto, Japan.
In this study, 31 subjects were orally administered 10mg corosolic acid or a placebo, on different occasions, in a capsule 5 min before the 75-g oral glucose tolerance test (OGTT). Nineteen subjects had diabetes, seven had impaired glucose tolerance, one had impaired fasting glucose, and four had normal glucose tolerance. There were no significant differences in plasma glucose levels before and 30min after the administration. Corosolic acid treatment subjects showed lower glucose levels from 60min until 120min and reached statistical significance at 90min. In this study, we have shown for the first time that corosolic acid has a lowering effect on postchallenge plasma glucose levels in vivo in humans.

Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.
Biol Pharm Bull. 2006. Miura T, Ueda N, Yamada K, Fukushima M, Ishida T. Department of Clinical Nutrition, Suzuka University of Medical Science, Mie, Japan.
The antidiabetic effects of corosolic acid were investigated in KK-Ay mice, an animal model of type 2 diabetes. Corosolic acid (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. Corosolic acid (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. Corosolic acid -treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that corosolic acid improves glucose metabolism by reducing insulin resistance. Therefore corosolic acid may be useful for the treatment of type 2 diabetes.

Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice.
Biol Pharm Bull. 2004. Department of Clinical Nutrition, Suzuka University Medical Science, Mie, Japan.
The effect of corosolic acid on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. Corosolic acid (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, corosolic acid did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally Corosolic acid -treated mice when compared with that of the controls. These results suggest that the hypoglycemic effect of corosolic acid is derived, at least in part, from an increase in GLUT4 translocation in muscle. Therefore, it may be that corosolic acid has beneficial effects on hyperglycemia in type 2 diabetes.

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