Banaba leaf extract corosolic acid efficiency

Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

Banaba (Lagerstroemia speciosa L.) has been used as a folk medicine to treat diabetes in various parts of the world, primarily southeast Asia. The hypoglycemic affect of aqueous (hot water) and methanol extracts have been demonstrated in several animal models as well as a number of human studies. Most studies have focused on corosolic acid which is isolated with an organic solvent from the leaves of the plant, and corosolic acid is used to standardize Banaba extracts,Some studies indicate that ellagitannins in water soluble fractions may be responsible for at least some of the insulin-like activity of Banaba, and the antioxidant and glucose regulatory properties of tannins.

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The above information about banaba extract is from the Internet and literature for reference only.

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