98% Neu5Ac, N-Acetylsialic Acid, NANA, Sialic Acid

About Sialic aicd

Sialic acids refer to a family of neuraminic acids which contain nine-carbon acidic amino monosaccharides. It was originally isolated from the mucin of the submandibular gland, hence the name.The most important member of the sialic acid is N-acetylneuraminic acid (Neus Ac or NANA) occuring most abundantly in glycoproteins and glycolipids. Among all types of sialic acids, only N-acetylneuraminic acid can be found in human tissues Therefore, sialic acid, to human beings, refers to N-acetylneuraminic acid. The yield of SA through microbial fermentation production. After bacteria and liquor separation, ultrafiltration and concentration, impurity removing (protein, soluble salt), polysialic acid purification polysialic acid hydrolysis purification, both of polysialic acid and N-acetylneuraminic acid reached a purity of more than 99% after purification detected by HPLC.

Sialic acid main function:

1.Sialic acid for anti-virus function.
2.Sialic acid for anti-cancer function.
3.Sialic acid for anti-inflammation function.
4.Sialic acid for defensive function against bacteriological infectiong.
5.Sialic acid for controlling ability of immune system.
6.Sialic acid for restraining ability against pigmentation.
7.Sialic acid for signal transformation in nerve cells.
8.Sialic acid for play a key role in brain development and learning.
9.Sialic acid for as precursor for the manufacture of many pharmaceutical drugs.

Sialic acid application:

1.Sialic acid for anti-inflammation;
2.Sialic acid for enhancing human immunity;
3.Sialic acid is known as mental development of “brain gold”;
4.Sialic acid used for cosmetics, food, health supplements;
5.Sialic acid adding infant milk powder can increase babys’ intelligence and memory;

Specification

ITEMSSTANDARDRESULT
AppearanceWhite powderConform
ImpuritiesNo visible impuritiesConform
SmellSweet and sour tasteConform
Assay>98.0%98.60%
pH1.8-2.32.11
Loss on Drying<2.0%1.50%
Transmittance>98.0%98.4%
Ignition Residue<2.0%0.12%
Aflatoxin B1<5.0^g/kgNot detected
Pb<1.0ppmNot detected
As<1.0ppmNot detected
Hg<0.2ppmNot detected
Total Plate Count<1,000cfU/g25cfu/g
Yeasts/Moulds<100cfu/gNot detected
Enterobacteriaceae<60MPN/100gNot detected
Staphylococcus AureusNot detectedNot detected
SalmonellaNot detectedNot detected

References:

1.Veh RW, Corfield AP, Sander M, Schauer R (1977) Biochim Biophys Acta 486:145–60.

2.Gahmberg CG, Anderson LC (1977) J Biol Chem 252:5888–94.

 3.Pfannschmidt G, Schauer R (1980) Hoppe-Seylers Z Physiol Chem 361:1683–95.

4.Howard RJ, Reuter G, Barnwell JW, Schauer R (1986) Parasitology 92:527–43.

5.Schauer R (1978) Methods Enzymol 50:64–89.

 6.Schauer R (1987) Methods Enzymol 138:132–61.

7.Vliegenthart JFG, Dorland L, van Halbeek H (1983) Adv Carbohydr Chem Biochem 41:209–374.

 8.Kamerling JP, Vliegenthart JFG (1982) Cell Biol Monogr 10:95–125.

 9.Kamerling JP, Vliegenthart JFG, Versluis C, Schauer R (1975) Carbohydr Res 41:7–17.

10.Reuter G, Schauer R (1986) Anal Biochem 157:39–46.

11.Schauer R, Corfield AP (1982) Cell Biol Monogr 10:77–94.

12JFG, Dorland L, van Halbeek H, Haverkamp J (1982) Cell Biol Monorg 10:127–72.

 13.Corfield AP, Schauer R (1982) Cell Biol Monogr 10:5–50.

 14 .Warren L (1959) J Biol Chem 234:1971–5.

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