γ-aminobutyric acid

Aminobutyric acid/GABA is a non-protein amino acid that functions as a neurotransmitter (a chemical that facilitates communication between neurons). Neurotransmitters are either “excitatory” (i.e. they stimulate the firing of a neuron) or “inhibitory” (i.e., they tend to suppress neuron firing). GABA, which is produced from glutamate, is an inhibitory neurotransmitter. In fact, it’s the primary inhibitory neurotransmitter in the brain. 

Aminobutyric acid main Function:

1.Beta Aminobutyric Acid is major neurotransmitter widely distributed throughout the central nervous system (CNS).

2.This neurotransmitter appears to have a significant influence on the pituitary gland’s hormone secretion, primarily through its hypothalamic effect.

3.Beta Aminobutyric Acid is also the most important and widespread inhibitory neurotransmitter in the brain.

4.It helps prevent the over-firing of the nerve cells and decreases overall neuron activities in the CNS. Over-firing can cause restlessness, spasmodic movements, irritability and anxiety.

5. Beta Aminobutyric Acid is also utilized by the brain to create tranquility and calmness through the brain’s metabolic processes.

Aminobutyric acid Application:

1.as raw materials for the medicines, health products and cosmetics.

2.directly adding into the tea, beverages and milk products.

3.as the natural ingredients used in coffee, chocolate, apple juice, cocoa, yogurt, milk sugar, butter, toast, bread, instant noodles and other functional food and drinks.

References:

  1. 1.R. A. Khaunina, Byull. Éksp. Biol., No. 1, 54 (1964).
  2. 2.T. Ya. Khvilivitskii, V.P. Belyaev, and M. Ya. Kolesnikova, in: Psychopharmacology and Treatment of Nervous and Psychiatric Disorders [in Russian], Leningrad (1964), pp. 22–23.
  3. 3.N. I. Kukoleva, in: Further Studies of the Somatic Basis and Treatment of Mental Disease (ed. by Ch. I. Kuibyshev) [in Russian] (1971), pp. 330–334.
  4. 4.L. L. Iversen and M. J. Neal, J. Neurochem.,15, 1141 (1968).
  5. 5.P. M. Beart and G. A. R. Johnston, J. Neurochem,20, 319 (1973).
  6. 6.P. M. Beart, G. A. R. Johnston, and M. L. Uhr, J. Neurochem.,19, 1855 (1972).
  7. 7.N. I. Maisov, N. L. Tolmacheva, and K. S. Raevskii, Farmakol. Toksikol., No. 5, 537 (1975). 
  8. 8.K. S. Raevskii, and N. I. Maisov, Byull.
  9. 9.D. L. Martin, and A. A. Smith, J. Neurochem.,19, 841 (1972).
  10. 10.A. A. Témp, and V. V. Perekalin, in: The Role of Gamma-Aminobutyric Acid in the Activity of the Nervous System [in Russian], Leningrad (1964), p. 39.
  11. 11.O. S. Vasil’eva, V. S. Grineva, M. M. Zobacheva, et al., in: Transactions of the A. I. Gertsen Pedagogical Institute. 26th Gertsenov Lecture [in Russian], Khimiya, Part 2, Leningrad (1973), pp. 25–30.
  12. 12.G. L. Klopkina, I. N. Rozental’, G.P. Kostrova, et al., Transactions of the A. I. Gertsen Pedagogical Institute. 26th Gertsenov Lecture [in Russian], Khimiya Part 2, Leningrad (1973), pp. 98–102.
  13. 13.M. J. Delphaut, Ann. Pharm. Fr.,14, 710 (1956).

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