Swertimarin

About swertimarin

Swertia , a Gentianaceae plant, mainly grow in China, India and Nepal. Swertiamarin is a class of Iiridoids extract from Swertia millensis which can reduce liver injury cause by toxicity substances and prevent for liver injury cause by absence of oxygen. Swertiamarin can also inhibit to central nervous system, it is a significant role of removing spasm and pain, it shows good effect as a treatment of gastroente ritis. Researches confirmed that swertiamarin show 50% inhibition rate to liver cancerunder consistency of 35~50μg. We can expect that Swertiamarin still have deeper level of research value as a new anti-cancer drugs.

 Swertia Extract Function

Swertia Bimaculata Extract has protecting liver, detoxification,blood enzyme,reduce liver splenomegaly, enhanceliver area ofmacrophage phagocytosis function.Swertiamarin has obvious inhibition hepatomacarcinoma cell function;

1.Swertia Bimaculata Extract direct effects on intestinal smooth muscle and spasmolysis;

2.Swertia Bimaculata Extract has significant analgesic and sedation,can treat gastrointestinal pain;

3.Swertia Bimaculata Extract have anti-inflammatory, antiviral effect,can expandcapillaries, and activate or promoteskin cell enzyme system, improve the biochemical function of skin cells

Swertia Extract Application:

1.Applied in the pharmaceutical field as medicine l raw materials;

2.Applied in the health care products field;

3.Applied in the food and beverage industry field.

For more product information pls contact email sales09@staherb.cn

references:

1.Arumugam N, Mukhopadhyay A, Gupta V, Sodhi YS, Verma JK, Pental D, Pradhan AK (2002) Synthesis of somatic hybrids (RCBB) by fusing heat-tolerant Raphnus sativus (RR) and Brassica oleracea (CC) with Brassica nigra (BB). Plant Breed 121:168–70

2.Cai YF, Xiang FN, Zhi DY, Liu H, Xia GM (2007) Genotyping of somatic hybrids between Festuca arundinacea Schreb. and Triticum aestivum L. Plant Cell Rep 26:1809–19

3.Cai YF, Liu YL, Liu ZH, Zhang F, Xiang FN, Xia GM (2009) High-grequency embryogenesis and regeneration of plants with high content of gentiopicroside from the Chinese medicinal plant Gentiana straminea Maxim. In Vitro Cell Dev Biol-Plant 45(6):730–9

4.de Vries SE, Ferwerda MA, Loonen AEHM, Pijnacker LP, Feenstra WJ (1987) Chromosomes in somatic hybrids between Nicotiana plumbaginifolia and a monoploid potato. Thero Appl Genet 75:170–6

5.Deng JY, Cui HF, Zhi DY, Zhou CE, Xia GM (2007) Analysis of remote asymmetric somatic hybrids between common wheat and Arabidopsis thaliana. Plant Cell Rep 26:1233–41

6.Doyle JJ, Doyle JI (1990) Isolation of plant DNA from fresh tissue. Focus 12:13–15

7.Dudits D, Maroy D, Praznovzky T (1987) Transfer of resistance trait from carrot into tobacco by asymmetric somatic hybridization: regeneration of fertile plants. Proc Natl Acad Sci USA, 84: 8434–8.

8.Endo T, Komiya T, Mino M, Nakanishi K, Fujita S, Yamada Y (1988) Genetic diversity among sublines originating from a single somatic hybrid cell of Duboisia hopwoodii + Nicotiana tabacum. Theor Appl Genet 76:641–6

9.Escanlante A, Imanishi S, Hossain M, Ohmido N, Fukui K (1998) RFLP analysis and genomic in situ hybridization (GISH) in somatic hybrids and their progeny between Lycopersicon esculentum and Solanum lycopersicoides. Theor Appl Genet 96:719–26

10.Gaikwad K, Kirti PB, Sharma A, Parkash S, Chopra VL (1996) Cytogenetical and molecular investigations on somatic hybrids of Sinapsis alba and Brassica juncea and their backcross progeny. Plant Breed 115:480–3

11.Gamborg OL, Miller RA, Ojina K (1968) Nutritional requirements of suspension cultures of soybean root cells. Exp Cell Res 50:151–8

12.Grosser JW, Gmitter FG (2004) SIVB congress symposium proceedings “Thinking outside the cell”: applications of somatic hybridization and cybridization in crop improvement, with citrus as a model. In Vitro Cel Dev Biol-Plant 41:220–5, 2005

13.Grosser JW, Ollitrault P, Olivares-Fuster O (2000) Somatic hybridization in citrus: an effective tool to facilitate variety improvement. In Vitro Cell Dev Biol-Plant 36:434–49

14.Han L, Zhou CN, Shi JY, Zhi DY, Xia GM (2009) Ginsenoside Rb1 in asymmetric somatic hybrid calli of Daucus carota with Panax quinquefolius. Plant Cell Rep 28:

15.Inouye H, Nakamura Y (1971) Studies on monoterpene glucosides and related natural products. XVI. Occurrence of secoiridoid glucosides in gentianaceous plants especially in the genera Gentiana and Swertia. Yakugaku Zasshi 91:755–9

16.Ishii T, Mori N, Ogihara Y (2001) Evaluation of allelic diversity at chloroplast microsatellite loci among common wheat and its ancestral species. Theor Appl Genet 103:896–904

17.Jelodar NB, Blackhall NW, Hartman TPV, Brar DS, Khush G, Davey MR, Cocking EC, Power JB (1999) Intergeneric somatic hybrids of rice [Oryza sativa L. (+) Porteresia coarctata (Roxb) Tateoka]. Theor Appl Genet 99:570–7

18.Kisaka H, Kisaka M, Kanno A, Kameya T (1998) Intergeneric somatic hybridization of rice (Oryza sativa L.) and barley (Hordeum vulgare L.) by protoplast fusion. Plant Cell Rep 17:362–7

19.Kostenyuk I, Lubaretz O, Borisyuk N, Voronin V, Stockigt J, Gleba Y (1991) Isolation and characterization of intergeneric somatic hybrids in the Apocynaceae family. Theor Appl Genet 82:713–16

20.Leino M, Teixeira R, Landgren M, Glimelius K (2003) Brassica napus lines with rearranged Arabidopsis mitochondria display CMS and a range of developmental aberrations. Theor Appl Genet 106:1156–63

21.Liu B, Liu ZL, Li XW (1999) Production of a highly asymmetric somatic hybrid between rice and Zizania latifolia (Griseb): evidence for inter-genomic exchange. Theor Appl Genet 98:1099–103

22.Liu JH, Xu XY, Deng XX (2005) Intergeneric somatic hybridization and its application to crop genetic improvement. Plant Cell Tissue Org Cult 82:19–44

23.Loyola-Vargas VM, Galaz-Avalos RM, Kú-Cauich R (2007) Catharanthus biosynthetic enzymes: the road ahead. Phytochem Rev 6:307–40

24.Melzer JM, O’Connell MA (1992) Effect of radiation dose on the production of and the extent of asymmetry in tomato asymmetric somatic hybrids. Theor Appl Genet 83:337–44

25.Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays from tobacco tissue cultures. Physiol Plant 15:473–97

26.Oberwalder B, Schilde-Rentschler L, Ruoß B, Wittemann S, Ninnemann H (1998) Asymmetric protoplast fusion between wild species and breeding lines of potato – effect of recipients genome stability. Theor Appl Genet 97:1347–54

27.Oudin A, Courtois M, Rideau M, Clastre M (2007) The iridoid pathway in Catharanthus roseus alkaloid biosynthesis. Phytochem Rev 6:259–76

28.Pental D, Hamill JD, Pirri A, Cocking EC (1986) Somatic hybridization of Nicotiana tabacum and Petunia hybrida. Recovery of plants with P. hybrida nuclear genome and N. tabacum chloroplast genome. Mol Gen Genet 202:342–7

29.Prakash S, Bhat SR, Quiros CF, Kirti PB, Chopra VL (2009) Brassica and its close allies: cytogenetics and evolution. Plant Breed Rev 31:21–187

30.Shi Q, Nie SQ, Huang LQ (2002) New progression of chemical component and pharmacological studies of Radix bupleuri. Chin J Exp Tradit Med Formulae 8:53–6

31.Song XQ, Xia GM, Zhou AF, Bao XZ, Chen HM (1999) Production of plants from somatic hybridization between Vitis vinifera L. and Bupleurum scorzonerifolium Willd in different families. Chin Sci Bull 44:1832–36

32.Szarka B, Gonter L, Mlonar-lang M, Morocz S, Dudits D (2002) Mixing of maize and wheat genomic DNA by somatic hybridization in regenerated sterile maize plants. Theor Appl Genet 105:1–7

33.Takeda Y, Inouye H (1976) Studies on monoterpene glucoside and related natural products. XXX. The fate of the C-8 proton of 7-deoxyloganic acid in the biosynthesis of secoiridoid glucosides. Chem Pharm Bull 24:79–84

34.Vaidya H, Rajani M, Sudarsanam V, Padh H, Goyal R (2009) Swertiamarin: a lead from Enicostemma littorale Blume. for anti-hyperlipidaemic effect. Eur J Pharmacol 617:108–12

35.Vlahova M, Hinnisdaels S, Frulleux F, Claeys M, Atanassov A, Jacobs M (1997) UV irradiation as a tool for obtaining asymmetric somatic hybrids between Nicotiana plumbaginifolia and Lycoperdicon esculentum. Theor Appl Genet 94:184–91

36.Wang MQ, Xia GM, Peng ZY (2005) High UV-tolerence with introgression hybrid formation of Bupleurum scorzonerifolium Willd. Plant Sci 168:593–600

37.Wang JF, Liu YL, Cai YF, Zhang FF, Xia GM, Xiang FN (2010) Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch. Biosci Biotechnol Biochem 74(8):1583–90

38.Xia GM, Chen HM (1996) Plant regeneration from intergeneric somatic hybridization between Triticum aestivum L. and Leymus chinensis (Trin.) Tzvel. Plant Sci 120:197–203

39.Xia GM, Li ZY, Chen HM (1992) Direct somatic embryogenesis and plant regeneration from protoplasts of Bupleurum scorzonerifolium Willd. Plant Cell Rep 11:155–8

40.Xia GM, Li ZY, Wang SL, Xiang FN, Liu JY, Chen PD, Liu DJ (1998) Asymmetric somatic hybridization between haploid wheat and UV irradiated Haynaldia villosa. Plant Sci 37:217–23

41.Xia GM, Chen SY, Xiang FN, Quan TY, Chen HM (2001) Study on salt-tolerance of F3-F5 hybrids originated from somatic hybridizaiton between wheat and Agropyron elongatum. Shandong Agri Sci 39(6):12–14

42.Xiang FN, Xia GM, Zhou AF, Chen HM (1999) Asymmetric somatic hybridization between wheat (Triticum aestivum L.) and Bromus inermis. Acta Bot Sin 41:458–62

43.Xiang FN, Xia GM, Chen HM (2003) Effect of UV dosage on somatic hybridization between common wheat (Triticum aestivum L.) and Avena sativa L. Plant Sci 164:697–707

44.Xiang FN, Wang JF, Xu CH, Xia GM (2010) The chromosome content and genotype of two wheat cell lines and of their somatic fusion product with oat. Planta 231:1201–10

45.Xu CH, Xia GM, Zhi DY, Xiang FN, Chen HM (2003) Integration of maize nuclear and mitochondrial DNA into the wheat genome through somatic hybridization. Plant Sci 165:1001–8

46.Yemets AI, Kundel’chuk OP, Smertenko AP, Solodushko VG, Rudas VA, Gleba YY, Blume YB (2000) Transfer of amiprophosmethyl resistance from a Nicotiana plumbaginifolia mutant by somatic hybridisation. Theor Appl Genet 100:847–57

47.Zhou AF, Xia GM (2005) Introgression of the Haynaldia villosa genome into c-ray-induced asymmetric somatic hybrids of wheat. Plant Cell Rep 24:289–96

48.Zhou AF, Xia GM, Zhang XY, Chen HM, Hu H (2001) Analysis of chromosomal and organellar DNA of somatic hybrids between Triticum aestivum and Haynaldia villosa Schur. Mol Genet Genom 26:5387–93

发表评论

电子邮件地址不会被公开。 必填项已用*标注