What is Broccoli extract?
Broccoli is also called cauliflower. It is the mutation of brassica oleracea, which belongs to brassica, cruciferae. The edible part is the green tender flower stalk and bud. It contains lots of nourishment, such as protein, sugar, fat, vitamin and carotene etc. It is honored as the “crown of the vegetables”.
Sulforaphane is an organosulfur compound that exhibits anticancer, antidiabetic, and antimicrobial properties in experimental models. It is obtained from cruciferous vegetables such as broccoli, Brussels sprouts or cabbages. The enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing). Young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.
Broccoli extract sulforaphane Application:
1. Applied in food field, broccoli extract is a kind of ideal green food to reduce weight;
2. Applied in health product field, celery can stable mood and eliminate irritable;
3. Applied in pharmaceutical field, to treat rheumatism and gout has good effect.
Broccoli extract sulforaphane Function:
1.Broccoli extract can prevent skin cancer when applied directly to the skin.
2.Broccoli extract could promote lung health.
3.Broccoli extract is a long-lasting anti-oxidant and detoxifier, and to contribute to the integrity offcells,promoting the body’s immune defense systems for overall health and well being.
4.Broccoli extract has been shown to be able to restore antioxidant gene.
For more product information pls kindly contact email firstname.lastname@example.org
Products of Analysis
|Certificate of Analysis|
|Particle size||100% pass 80 mesh||Complies|
|Loss on drying||5.0% Max||1.91%|
|Heavy metals||10ppm Max||Complies|
|Total plate count||1000cfu/g Max||Complies|
|Yeast & Mold||100cfu/g Max||Complies|
|Conclusion||Complies with the standards.|
1.L. M. Coussens, and Z. Werb. Inflammation and cancer. Nature. 420(6917):860–7 (2002).
2.M. M. Muller. Inflammation in epithelial skin tumours: old stories and new ideas. Eur. J. Cancer. 42(6):735–44 (2006). doi:10.1016/j.ejca.2006.01.014.
3.B. J. Rollins. Inflammatory chemokines in cancer growth and progression. Eur. J. Cancer. 42(6):760–7 (2006). doi:10.1016/j.ejca.2006.01.002.
4.H. Lu, W. Ouyang, and C. Huang. Inflammation, a key event in cancer development. Mol. Cancer Res. 4(4):221–33 (2006). doi:10.1158/1541–7786.MCR-05–0261.
5.P. Szlosarek, K. A. Charles, and F. R. Balkwill. Tumour necrosis factor-alpha as a tumour promoter. Eur. J. Cancer. 42(6):745–50 (2006). doi:10.1016/j.ejca.2006.01.012.
6.Q. Li, S. Withoff, and I. M. Verma. Inflammation-associated cancer: NF-kappaB is the lynchpin. Trends. Immunol. 26(6):318–25 (2005). doi:10.1016/j.it.2005.04.003.
7.L. S. Angelo, and R. Kurzrock. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin. Cancer Res. 13(10):2825–30 (2007).
8.P. Rose, Y. K. Won, C. N. Ong, and M. Whiteman. Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages.
9.H. Gradisar, M. M. Keber, P. Pristovsek, and R. Jerala. MD-2 as the target of curcumin in the inhibition of response to LPS. J. Leukoc. Biol. 82(4):968–74 (2007).
10.I. Brouet, and H. Ohshima. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem. Biophys. Res. Commun. 206(2):533–40 (1995)
11.M. M. Chan, H. I. Huang, M. R. Fenton, and D. Fong. In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem. Pharmacol. 55(12):1955–62 (1998).
12.G. Y. Kim, K. H. Kim, S. H. Lee, M. S. Yoon, H. J. Lee, D. O. Moon, C. M. Lee, S. C. Ahn, Y. C. Park, and Y. M. Park. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J. Immunol. 174(12):8116–8124 (2005).
13.L. Wu, M. H. Noyan Ashraf, M. Facci, R. Wang, P. G. Paterson, A. Ferrie, and B. H. Juurlink. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc. Natl. Acad. Sci. USA. 101(18):7094–9 (2004).
14.P. Talalay, J. W. Fahey, Z. R. Healy, S. L. Wehage, A. L. Benedict, C. Min, and A. T. Dinkova-Kostova. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc. Natl. Acad. Sci. USA. 104(44):17500–17505 (2007)
15.T. C. Chou. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 58(3):621–81 (2006).
16.S. Nair, V. Hebbar, G. Shen, A. Gopalakrishnan, T. O. Khor, S. Yu, C. Xu, and A. N. Kong. Synergistic Effects of a Combination of Dietary Factors Sulforaphane and (−) Epigallocatechin-3-gallate in HT-29 AP-1 Human Colon Carcinoma Cells. Pharm. Res. 25(2):387–99 (2008).
17.G. Shen, T. O. Khor, R. Hu, S. Yu, S. Nair, C. T. Ho, B. S. Reddy, M. T. Huang, H. L. Newmark, and A. N. Kong. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/ + mouse. Cancer Res. 67(20):9937–44 (2007).
18.G. Shen, C. Xu, R. Hu, M. R. Jain, A. Gopalkrishnan, S. Nair, M. T. Huang, J. Y. Chan, and A. N. Kong. Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Mol. Cancer Ther. 5(1):39–51 (2006).
19.E. Balogun, M. Hoque, P. Gong, E. Killeen, C. J. Green, R. Foresti, J. Alam, and R. Motterlini. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371(Pt 3):887–895 (2003).
20.C. Xu, G. Shen, C. Chen, C. Gélinas, and A. N. Kong. Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene. 24(28):4486–95 (2005).
21.E. Lázár-Molnár, H. Hegyesi, S. Tóth, and A. Falus. Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine. 12(6):547–54 (2000).
22.W. W. Lin, and M. Karin. A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 117(5):1175–83 (2007).
23.N. Li, J. Alam, M. I. Venkatesan, A. Eiguren-Fernandez, D. Schmitz, E. Di Stefano, N. Slaughter, E. Killeen, X. Wang, A. Huang, M. Wang, A. H. Miguel, A. Cho, C. Sioutas, and A. E. Nel. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J. Immunol. 173(5):3467–81 (2004).
24.X. L. Chen, and C. Kunsch. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr. Pharm. Des. 10(8):879–91 (2004)
25.C. C. Lin, X. M. Liu, K. Peyton, H. Wang, W. C. Yang, S. J. Lin, and W. Durante. Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. Arterioscler. Thromb. Vasc. Biol. 28(4):739–45 (2008).
26.W. W. Wang, D. L. Smith, and S. D. Zucker. Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology. 40(2):424–33 (2004).
27.R. K. Thimmulappa, H. Lee, T. Rangasamy, S. P. Reddy, M. Yamamoto, T. W. Kensler, and S. Biswal. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J. Clin. Invest. 116(4):984–95 (2006).