Berberine hydrochloride is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis (e.g. Berberis aquifolium (Oregon grape), Berberis vulgaris (Barberry), and Berberis aristata (Tree Turmeric)), Hydrastis canadensis (Goldenseal), Phellodendron amurense (Amur Cork Tree, Huang Bai, Huang Po, Po Mu) and Coptis chinensis (Chinese Goldthread, Huang-Lian, Huang-Lien), and Tinospora cordifolia, and to a smaller extent in Argemone mexicana (Prickly Poppy) and Eschscholzia californica (Californian Poppy). Berberine HCL is usually found in the roots, rhizomes, stems, and bark.
Berberine HCL main Function:
1. Berberine HCL has the function of removing heat and damp, relieving fire and eliminating toxins;
2. Berberine HCL has the function of anti-inflammatory, antibacterial, antiviral, and antigens worm; And it has obvious inhibition to influenza viruses;
3. Berberine HCL has the function of relaxing vascular smooth muscle, and anti diarrhea;
4. Berberine HCL has the function of resisting arrhythmia, lowering presue, and regulating blood level;
5. Berberine HCL With the function of cholagogue, it can increase bile secreted;
6. Berberine HCL has anti cerebral ischemia effect, it can anti-oxygen free radical and reduce cerebral inland.
Berberine HCL Application:
1. It is used against asthma, diarrhoea, cholera, verminosis and gastralgia dyspepsia
2. It is used in lumbago, hysteria, dyspepsia and worm affection.
3. It is used as surfactant and used for washing hairs and fabrics.
For more product information pls contact email firstname.lastname@example.org
|Particle size||100% pass through 80 mesh sieve|
|Loss on drying(5h at105°C)||≤5.0%|
|Ash(3h at 600°C)||≤5.0%|
|Total Heavy Metals||≤10ppm|
|Residual Solvents||Eur. Pharm. 2000|
|Total bacterial count||Max.1000cfu/g|
|Yeast & Mould||Max.100cfu /g|
|Escherichia coli presence||Negative|
1.Kawano Y, Ito A, Sasatsu M, Machida Y. Preparation of orally disintegrating tablets with taste-masking function: masking effect in granules prepared with correctives using the dry granulation method and evaluation of tablets prepared using the taste-masked granules. Yakugaku Zasshi. 2010;130:81–6.
2.Anderson O, Zweidorff OK, Hjelde T. Problems when swallowing tablets. A questionnaire study from general practice. Tidsskr Nor Laegeforen. 1995;20:947–9.
3.USFDA, Center for Drug Evaluation and Research (CDER). 2008. Guidance for industry orally disintegrating tablets. http://www.fda.gov/cder/guidance. Accessed 15 July 2010.
4.Douroumis D. Orally disintegrating dosage forms and taste-masking technologies; 2010. Expert Opin Drug Deliv. 2011;8:665–75.
5.Kawano Y, Ito A, Sasatsu M, Machida Y, Onishi H. Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method. Yakugaku Zasshi. 2010;130:1737–42.
6.Lu MY, Borodkin S, Woodward L, Li P, Diesner C, Hernandez L, et al. A polymer carrier system for taste masking of macrolide antibiotics. Pharm Res. 1991;8:706–12.
7.Bhise K, Shaikh S, Bora D. Taste mask, design and evaluation of an oral formulation using ion exchange resin as drug carrier. AAPS PharmSciTech. 2008;9:557–62.
8.Szejtli J, Szente L. Elimination of bitter, disgusting tastes of drugs and foods by cyclodextrins. Eur J Pharm Biopharm. 2005;61:115–25.
9.Ishikawa T, Watanabe Y, Utoguchi N, Matsumoto M. Preparation and evaluation of tablets rapidly disintegrating in saliva containing bitter-taste-masked granules by the compression method. Chem Pharm Bull. 1999;47:1451–4.
10.Khan S, Kataria P, Nakhat P. Taste masking of ondansetron hydrochloride by polymer carrier system and formulation of rapid-disintegrating tablets. AAPS PharmSciTech. 2007;8:E46.
11.Yan YD, Woo JS, Kang JH, Yong CS, Choi HG. Preparation and evaluation of taste-masked donepezil hydrochloride orally disintegrating tablets. Biol Pharm Bull. 2010;33:1364–70.
12.Löbenberg R, Krämer J, Shah VP, Amidon GL, Dressman JB. Dissolution testing as a prognostic tool for oral drug absorption: dissolution behavior of glibenclamide. Pharm Res. 2000;17:439–44.
13.Yoshida T, Tasaki H, Maeda A, Katsuma M, Sakoa K, Uchidac T. Salting-out taste-masking system generates lag time with subsequent immediate release. Int J Pharm. 2009;365:81–8.
14.Shah PP, Mashru RC, Rane YM, Badhan AC. Design and optimization of artemether microparticles for bitter taste masking. Acta Pharm. 2008;58:379–92.
15.Ishikawa T, Mukai B, Shiraishi S, Utoguchi N, Fujii M, Matsumoto M, et al. Preparation of rapidly disintegrating tablet using new types of microcrystalline cellulose (PH-M series) and low substituted-hydroxypropylcellulose or spherical sugar granules by direct compression method. Chem Pharm Bull. 2001;49:134–9.
16.Uchida T, Nakamura T, Tanigake A, Miyanaga Y, Ogawa T. The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies. Chem Pharm Bull. 2002;50:1589–93.
17.Kawashima Y, Takeuchi H, Hino T, Niwa T, Lin TL, Sekigawa F, et al. Low-substituted hydroxypropylcellulose as a sustained-drug release matrix base or disintegrant depending on its particle size and loading in formulation. Pharm Res. 1993;10:351–5.
18.Sugao H, Yamazaki S, Shiozawa H, Yano K. Taste masking of bitter drug powder without loss of bioavailability by heat treatment of wax-coated microparticles. J Pharm Sci. 1998;87:96–100.
19.Sheshala R, Khan N, Darwis Y. Formulation and optimization of orally disintegrating tablets of sumatriptan succinate. Chem Pharm Bull. 2011;59:920–8.
20.Battu SK, Repka MA, Majumdar S, Madhusudan RY. Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of superdisintegrants. Drug Dev Ind Pharm. 2007;33:1225–32.
21.Madan J, Sharma AK, Singh R. Fast dissolving tablets of Aloe vera gel. Trop J Pharm Res. 2009;8:63–70.
22.Morita Y, Tsushima Y, Termoz R, Ajioka J, Takayama K. Evaluation of disintegration time of rapidly disintegrating tablets via a novel method utilizing a CCD camera. Chem Pharm Bull. 2002;50:1181–6.
23.Shibata Y, Yamamoto Y, Fujii M, Kondoh M, Watanabe Y. A novel method for predicting disintegration time in the mouth of rapidly disintegrating tablet by compaction analysis using TabAll. Chem Pharm Bull. 2004;52:1394–5.
24.Narazaki R, Harada T, Takami N, Kato Y, Ohwaki T. A new method for disintegration studies of rapid disintegrating tablets. Chem Pharm Bull. 2004;52:704–7.
25.Rawas-Qalaji MM, Simons FE, Simons KJ. Fast-disintegrating sublingual tablets: effect of epinephrine load on tablet characteristics. AAPS PharmSciTech. 2006;7:E41.
26.Diem K, Lentner C. Scientific tables. Basle: Ciba-Geigy Limited; 1971.