baicalein

About the Skullcap:

Skullcap is a plant. The above ground parts are used to make medicine.  

Skullcap is used for many conditions, but so far, there isn’t enough scientific evidence to determine whether or not it is effective for any of them.   Skullcap is used for trouble sleeping (insomnia), anxiety, stroke, and paralysis caused by stroke. It is also used for fever, high cholesterol, “hardening of the arteries” (atherosclerosis), rabies, epilepsy, nervous tension, allergies, skin infections, inflammation, and spasms.  

Skullcap products are not always what the labels claim. The plants germander and teucrium are often unwanted and unlabeled ingredients in skullcap products. Secondly, you may think you are buying Scuttelaria lateriflora, the species of skullcap that has been studied for medicinal use, but the product may contain a different species of skullcap instead.    

The most often substituted species are Western Skullcap (Scuttelaria canescens), Southern Skullcap (Scutellaria cordifolia), or Marsh Skullcap (Scutellaria galericulatum). These species contain different chemicals, so they are not considered interchangeable.   Baical skullcap has been used for anti-inflammatory, antioxidant, immunoprotective, anticancer, antimicrobial, antiviral, and circulatory conditions. Several chemical compounds have been isolated from the root; baicalein, baicalin, wogonin, norwogonin, oroxylin A and βsitosterol are the major ones.

For more product information pls contact email sales09@staherb.cn

Functions

1. It had significant anti-inflammatory &anti-allergic antibacterial effects;

2. It can clear heat &deprive the wetness, with the function of diuresis &Sedation&preventing miscarriage &stop bleeding;

3. Baicalin will reduce cerebral vascular resistance, improve blood circulation, increase cerebral blood flow and has anti-platelet aggregation effect;

4. It can lower blood pressure& Reduce lipid.

Applications:

1.Baicalin be used for the treatment of paralysis after cerebrovascular disease.

2.Baicalin can remove oxygen free radicals, but also inhibit the melanin.

3.Baicalin will reduce cerebral vascular resistance, improve blood circulation, increase cerebral blood flow and has anti-platelet aggregation effect.

4.Baicalin has antibacterial, diuretic, anti-inflammatory, anti-metamorphosis and antispasmodic effect。

references:

1.Upadhyay KK, Bhatt AN, Mishra AK et al (2010) The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(gamma-benzyl L-glutamate)-b-hyaluronan polymersomes. Biomaterials 31:2882–2892

2.Aluise CD, Miriyala S, Noel T et al (2011) 2- Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-alpha release: implications for the reactive oxygen species-mediated mechanisms of chemobrain. Free Radic Biol Med 50:1630–1638

3.Rashid S, Ali N, Nafees S et al (2013) Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats. Toxicol Mech Methods 23(5):337–345

4.Kalender Y, Yel M, Kalender S (2005) Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: the effects of vitamin E and catechin. Toxicology 209(1):39–45

5.Lee V, Randhawa AK, Singal PK (1991) Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals. Am J Physiol Heart Circ Physiol 261(4):989–995

6.Marchand DJ, Renton KW (1981) Depression of cytochrome P-450-dependent drug biotransformation by adriamycin. Toxicol Appl Pharmacol 58(1):83–88

7.Damodara RV, Saayi KG, Padmavathi P et al (2007) Effect of Emblica officinalis against alcohol-induced biochemical changes in plasma and red blood cells of rats. Afr J Biochem Res 1(6):101–105

8.Mohan M, Kamble S, Gadhi P et al (2010) Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats. Food Chem Toxicol 48(1):436–440

9.Rašković A, Stilinović N, Kolarović J et al (2011) The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules 16(10):8601–8613

10.Saad SY, Najjar TA, Al-Rikabi AC (2001) The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. Pharmacol Res 43(3):211–218

11.Toko H, Oka T, Zou Y et al (2002) Angiotensin II type 1a receptor mediates doxorubicin-induced cardiomyopathy. Hypertens Res 25:597–603

12.Matouk AI, Taye A, Heeba GH et al (2013) Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats. Environ Toxicol Pharmacol 36:443–450

13.Xiao L, Hu SQ, Wang LY et al (2015) Losartan improves the distribution and efficacy of doxorubicin in CT26 tumor. Eur Rev Med Pharmacol Sci 19:3763–3769

14.Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J Nutr Sci 5:e47

15.Ginwala R, Bhavsar R, Chigbu DI et al (2019) Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin. Antioxidants (Basel) 8(2):35

16.Al-Oanzi ZH (2019) Erectile dysfunction attenuation by naringenin in streptozotocin-induced diabetic rats. J Food Biochem 43(7):e12885

17.Patwardhan RS, Sharma D, Thoh M et al (2016) Baicalein exhibits anti-inflammatory effects via inhibition of NF-κB transactivation. Biochem Pharmacol 15(108):75–89

18.Fu Y, Luo J, Jia Z et al (2014) Baicalein protects against type 2 diabetes via promoting islet β-cell function in obese diabetic mice. Int J Endocrinol 2014:846742

19.Yun BY, Zhou L, Xie KP et al (2012) Antibacterial activity and mechanism of baicalein. Yao Xue Xue Bao 47(12):1587–1592

20.Lu Y, Joerger R, Wu C (2011) Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. J Agric Food Chem 59(20):10934–10942

21.Palko-Labuz A, Sroda-Pomianek K, Uryga A et al (2017) Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells. Biomed Pharmacother 88:232–241

22.Huang Y, Tsang SY, Yao X et al (2005) Biological properties of baicaleinin cardiovascular system. Curr Drug Targets Cardiovasc Haematol Disord 5:177–184

23.Stavniichuk R, Drel VR, Shevalye H et al (2011) Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation. Exp Neurol 230:106–113

24.Shiromwar SS, Chidrawar VR (2011) Combined effects of p-coumaric acid and naringenin against doxorubicin-induced cardiotoxicity in rats. Pharmacogn Res 3:214–219

25.Cappetta D, De Angelis A, Sapio L et al (2017) Oxidative stress and cellular response to doxorubicin: a common factor in the complex milieu of anthracycline cardiotoxicity. Oxid Med Cell Longev 2017:13

26.Akolkar G, da Silva DD, Ayyappan P et al (2017) Vitamin C mitigates oxidative/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol 313:795–809

27.Al-Harthi SE, Alarabi OM, Ramadan WS et al (2014) Amelioration of doxorubicin-induced cardiotoxicity by resveratrol. Mol Med Rep 10(3):1455–1460

28.Imam F, Al-Harbi NO, Al-Harbi MM et al (2018) Apremilast prevent doxorubicin-induced apoptosis and inflammation in heart through inhibition of oxidative stress mediated activation of NF-kappaB signaling pathways. Pharmacol Rep 70:993–1000

29.Kabel AM, Alzahrani AA, Bawazir NM et al (2018) Targeting the proinflammatory cytokines, oxidative stress, apoptosis and TGF-beta1/STAT-3 signaling by irbesartan to ameliorate doxorubicin-induced hepatotoxicity. J Infect Chemother 24:623–631

30.Chang SA, Lim BK, Lee YJ et al (2015) A novel angiotensin type I receptor antagonist, fimasartan, prevents doxorubicin-induced cardiotoxicity in rats. J Korean Med Sci 30:559–568

31.Hrenak J, Arendasova K, Rajkovicova R et al (2013) Protective effect of captopril, olmesartan, melatonin and compound 21 on doxorubicin-induced nephrotoxicity in rats. Physiol Res 62(Suppl 1):S181

32.Koba S, Angiotensin II (2018) Oxidative stress, and sympathetic nervous system hyperactivity in heart failure. Yonago Acta Med 61:103–109

33.Li XX, He GR, Mu X et al (2012) Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria. Eur J Pharmacol 674:227–233

34.Hadi N, Yousif NG, Al-amran FG et al (2012) Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response. BMC Cardiovasc Disord 12:63

35.Sahu BD, Kumar JM, Kuncha M et al (2016) Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice. Life Sci 1(144):8–18

36.Siveski-Iliskovic N, Kaul N, Singal PK (1994) Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 89:2829–2835

发表评论

电子邮件地址不会被公开。 必填项已用*标注