Phlorizin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. Phlorizin may be a novel therapeutic approach for the treatment of diabetic nephrolog, it protects mice from diabetic nephrology. Phlorizin prevents ventricular tachyarrhythmia through the improvement of impulse conduction slowing during ischemia.

Phlorizin is naturally occurring in some plants. It could be found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees (Rosaceae).It can be used as medicine additives,functional food additives,cosmetic additives ect.

 Phlorizin Function:

1.Anti Aging

Functional declines associated with aging

Restrict related disease lead to aging

2.Diabetes

Lower risk for the diabetes diseases

3.Fat loss

Lower blood glucose level

4.Anti-cancer

Prevent from lung cancer

Prevent from breast cancer

Prevent from skin cancer

Prevent from colon cancer 

5.Cholesterol

Lower the serum cholesterol

Reduce the fat in the innards

6.Allergies

Anti-allergic effect of apple polyphenol on patients with atopic dermatitis Help maintain respiratory health even during the allegy season

7.Hair growth

Help the hair grow and make it black

8.Skin care

Whitening skin by limiting the formation of melanin

Prevention of the skin to the ultraviolet radiation

9.Oral care

Inhibit the halitosis caused by saliva during sleep and dental plaque.

Phlorizin Application:

1.Applied in food field, it aslo can be used as food additive and colorant;

2.Applied in health product field, black rice extract anthocyanidin capsule supply a new way to treat atherosclerotic cardiovascular disease;

3.Applied in cosmetic field, anthocyanidin is mainly used as antioxidant, preventing UV radiation

For more product information pls kindly contact email sales09@staherb.cn

 Product Analysis

Item	Specification	Test result
Physical Control
Appearance	White Fine Powder	Conforms
Odor	Characteristic	Conforms
Taste	Characteristic	Conforms
Part Used	Apple skin	Conforms
Loss on Drying	≤5.0%	Conforms
Ash	≤5.0%	Conforms
Particle size	100% pass 80 mesh	Conforms
Allergens	None	Conforms
Chemical Control
Heavy metals	NMT 10ppm	Conforms
Arsenic	NMT 2ppm	Conforms
Lead	NMT 2ppm	Conforms
Cadmium	NMT 2ppm	Conforms
Mercury	NMT 2ppm	Conforms
GMO Status	GMO Free	Conforms
Microbiological Control
Total Plate Count	10,000cfu/g Max	Conforms
Yeast & Mold	1,000cfu/g Max	Conforms
E.Coli	Negative	Negative
Salmonella	Negative	Negative

References：

1.Mayer, J. 1995. Regulation of energy balance and body weight: the glucostatic theory and the lipostatic hypothesis. Ann. NY Acad. Sci. 63:15–43.

2.Mayer, J. and Thomas, D. 1967. Regulation of food intake and obesity. Science 156:228–337.

3.Flynn, F. W. and Grill, H. J. 1985. Fourth ventricular phlorizin dissociates feeding from hyperglycemia in rats. Brain Res. 341:331–336.

4.Ritter, R. C., Slusser, P. C., and Stone, S. 1981. Glucoreceptors controlling feeding and blood glucose are in the hindbrain. Science 213:451–452.

5.Tordoff M. G., Flynn, F. W., Grill H. J., and Friedman, M. I. 1988. Contribution of fat metabolism to ‘glucoprivic’ feeding produced by fourth ventricular 5-thio-D-glucose. Brain Res. 445:216–221.

6.Panayotova-Heiermann, M., Loo, D. D., Kong, C. T., Lever, J. E., and Wright, E. M. 1996. Sugar binding to Na+/glucose cotransporters is determined by the carboxyl-terminal half of the protein. J. Biol. Chem. 271:10029–10034.

7.Poppe, R., Karbach, U., Gambaryan, S., Wiesinger, H., Lutzenburg, M., Kraemer, M., Witte, O. W., and Koepsell, H. 1997. Expression of the Na+-D-glucose cotransporter SGLT1 in neurons. J. Neurochem. 69:84–94.

8.Vannucci, S. G., Maher, F., and Simpson, I. A. 1997. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 21:2–21.

9.Lee, W. S., Kanai, Y., Wells, R. G., and Hediger, M. A. 1994. The high affinity Na+/glucose cotransporter. Re-evaluation of function and distribution of expression. J. Biol. Chem. 269:12032–12039.

10.Bissonnette, P., Gagne, H., Coady, M. J., Benabdallah, K., Lapointe, J. Y., and Berteloot, A. 1996. Kinetic separation and characterization of three sugar transport modes in Caco-2 cells. Amer. J. Physiol. 270:G833–843.

11.Brot-Larouche, E., Supplisson, S., Delhomme, B., Alcalde, A. I., and Alvarado, F. 1987. Characterization of the D-glucose/ Na+ cotransport system in the intestinal brush-border by using the specific substrate, methyl alpha-D-glucopyranoside. Biochim. Biophys. Acta 904:71–80.

12.Loike, J. D., Hickman, S., Kuang, K., Xu, M., Cao, L., Vera, J. C., Silverstein, S. C., and Fischbarg, J. 1996. Sodium-glucose cotransporters display sodium-and phlorizin-dependent water permeability. Amer. J. Physiol. 271:C1779–1774.

13.Malo, C. 1990. Separation of two distinct Na+/glucose cotransport systems in the human fetal jejunum by means of their differential specificity for 3-O-methylglucose. Biochim. Biophys. Acta 1022:8–16.

14.Morgan, J. I. and Curran, T. 1991. Stimulus-transcription coupling in the nervous system: involvement of the inducible protooncogenes fos and jun. Annu. Rev. Neurosci. 14:421–451.

15.Kasahara, T. and Kasahara, M. 1997. Characterization of rat Glut4 glucose transporter expressed in the yeast Saccharomyces cerevisiae: comparison with Glut1 glucose transporter. Biochim. Biophys. Acta 1324:111–119.

16.Ritzhaupt, A., Wood, I. S., Ellis, A., Hosie, K. B., and Shirazi-Beechey, S. P. 1998. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J. Physiol. 513:719–732.

17.Roeder, L. M., Williams, I. B., and Tildon, J. T. 1985. Glucose transport in astrocytes: regulation by thyroid hormone. J. Neurochem. 45:1653–1657.

18.Rosenberg, P. A. and Dichter, M. A. 1985. Glycogen accumulation in rat cerebral cortex in dissociated cell culture. J. Neurosci. Meth. 15:101–112.

19.Schurr, A., Payne, R. S., Miller J. J., and Rigor, B. M. 1997. Brain lactate is an obligatory aerobic energy substrate for functional recovery after hypoxia: further in vitro validation. J. Neurochem. 69:423–426.

20.Larabee M. G. 1995. Lactate metabolism and its effects on glucose metabolism in an excised neural tissue. J. Neurochem. 64:1734–1741.

21.Larabee M. G. 1996. Partitioning of CO2 production between glucose and lactate in excised sympathetic ganglia, with implications for brain. J. Neurochem. 67:1726–1734.

22.Dringen, R. and Hamprecht, B. 1992. Glucose, insulin, and insulin-like, growth factor I regulate the glycogen content in astroglia-rich primary cultures. J. Neurochem. 58:511–517.

23.Dringen, R. and Hamprecht, B. 1993. Differences in glycogen metabolism in astroglia-rich primary cultures and sorbitolselected astroglia cultures derived from mouse brain. Glia 8:143–149.

24.Hu, Y. and Wilson, G. S. 1997. A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J. Neurochem. 69:1484–1490.