Oleanolic acid

Chinese privet has been used in traditional Chinese medicine for over 1,000 years.The Oleanolic Acid is antibacterial,antiseptic,antitumour,cardiotonic,diuretic and tonic.It is taken internally in the treatment of complaints associated with weak kidney and liver energy such as menopausal problems (especially premature menopause),blurred vision,cataracts,tinnitus,rheumatic pains,palpitations,backache and insomnia.Modern research has shownthat the plant increases the white blood cell count and is of value when used to prevent bone marrow loss in cancer chemotherapy patients, it also has potential in the treatment of AIDS.Extracts of the plant show antitumour activity.Good results have also been achieved when the fruit has been used in treating respiratory tract infections,hypertension,Parkinson”s disease and hepatitis. 

Oleanolic acid application:

Oleanolic acid is a triterpenoid compound that is widespread in nature, in particular it occurs in leaves of Olea europea L. (Oleaceae). It has been long recognized to have hepatoprotective, antiinflammatory, and antihyperlipidemic properties

Oleanolic acid has been noted for its antitumor-promotion effect.

Oleanolic acid is effective in protecting against chemically induced liver injury in laboratory animals.

Oleanolic acid has been marketed in China as an oral drug for human liver disorders.

Oleanolic acid has also been long-recognized to have anti-inflammatory and antihyperlipidemic properties in laboratory animals, and more research is warranted to develop a therapy for patients.

Oleanolic acid is non-toxic, and has been used in cosmetics and health products. The possible mechanisms for the pharmacological effects and the prospects for these two compounds are discussed.

Oleanolic acid main function:

1. Anti-hepatitis, with the function of protecting liver.

2. Preventing and inhibiting the growth of tumor formation.

3. Anti-oxidant, especially on the respect of anti-aging and skin protected have a positive effect.

References:

1.B. Blessington and I. M. Morton, Org. Mass Spectrom.,3, 95 (1970).

2.B. Blessington, Y. Nakagawa, and D. Satoh, Org. Mass Spectrom.,4, 215 (1970).

3.P. Brown, F. Brüschweiler, R. Pettit, and T. Reichstein, Org. Mass Spectrom.,5, 573 (1971).

4.R. D. Schmid, Tetrahedron,28, 3259 (1972).

5.R. D. Schmid, P. Varenne, and R. Paris, Tetrahedron,28, 5037 (1972).

6.L. P. Vecherko, É. P. Zinkevich, N. I. Libizov, andA. I. Ban’kovskii, Khim. Prirodn. Soedin., 22 (1971).

7.H. Budzikiewicz, J. M. Wilson, and C. Djerassi, J. Am. Chem. Soc.,85, 3688 (1963).

8.N. K. Kochetkov, N. S. Wulfson (Vul’fson), O. S. Chizhov, and B. M. Zolotarev, Tetrahedron,19, 2209 (1963).

9.V. Kovacik, S. Baer, and I. Rosik, Carbohydrate Res.,8, 282 (1968).

10.S. Hakomori, J. Biochem.,55, 205 (1964).

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