Mangosteen extract mangostin

About the product

Mangosteen is a superfruit that contains a rich nutrient base along with the potential impact for lowering risk against various diseases. Long used in Southeast Asia for its health benefits, the tropical fruit is native to areas of Cambodia, China, Indonesia, Malaysia, Philippines, Singapore, Thailand and Vietnam.It is similar in size to a tangerine or mandarin orange, with a dark purple/reddish rind and white flesh. Like other tropical fruits, it is multi-segmented. The taste of the fruit is sweet, similar to a plum. However, instead of peeling a mangosteen like a tangerine, you should twist or press the fruit until it breaks apart. Uses in folk medicine of the mangosteen include cures from skin disorders to dysentery. The rind of mangosteen is used for several health conditions including diarrhea, bladder infections, gonorrhea and skin rashes. 

Specification:

Product Name:  Mangosteen Extract

Latin Name:  Garcinia mangostana

Appearance:  light yellow powder
Active Ingredient: Mangostin 

Specification:  : 10%-95%

Test method: HPLC

CAS No.: 6147-11-1

Molecular formula :C24H26O6

Extraction Type: Solvent extraction
Mesh: 100% pass 80 mesh 

Mangosteen extract main function:

 1. Anti-oxidant: Mangostin is the inhibitor of oxidation of LDL, which have major role in cardio-vascular and related chronic diseases.

2.Anti-allergies and inflammations: γ- mangostin was identified to inhibit COX.

3.Anti-virus and anti-bacteria: the polysaccharides in the extract form can stimulate phagocytic cells to kill intracellular bacteria.

4.Anti-cancer: Mangostin has been revealed to inhibit topoisomerase, which is essential for cell division in cancer cells, also could selectively induce cell apoptosis and inhibit cell division.

Mangosteen Extract Main Application:

1. Applied in food field, it is often made into juice or other drinks in the market;

2.Applied in health product and pharmaceutical field, it is widely used to prevent and treat various disease;

3.Applied in cosmetic field, it is widely used in the skin care products.

References:

1.Ohkawa Y, Miki K, Suzuki T, Nishio K, Sugita T, Kinoshita K, Takahashi K, Koyama K (2010) Antiangiogenic metabolites from marine-derived fungus, Hypocrea vinosa. J Nat Prod 73:579–582

2.Kaneko A, Tsukada M, Fukai M, Suzuki T, Nishio K, Miki K, Kinoshita K, Takahashi K, Koyama K (2010) KDR kinase inhibitor isolated from the mushroom Boletopsis leucomelas. J Nat Prod 73:1002–1004

3.Tsukada M, Fukai M, Miki K, Shiraishi T, Suzuki T, Nishio K, Sugita T, Ishino M, Kinoshita K, Takahashi K, Shiro M, Koyama K (2011) Chemical constituents of a marine fungus, Arthrinium sacchari. J Nat Prod 74:1645–1649

4.Fukai M, Tsukada M, Miki K, Suzuki T, Sugita T, Kinoshita K, Takahashi K, Shiro M, Koyama K (2012) Hypoxylonols C-F benzo[j]fluoranthenes from Hypoxylon truncatum. J Nat Prod 75:22–25

5.Olsson AK, Dimberg A, Kreuger J, Claesson WL (2006) VEGF receptor signaling—in control of vascular function. Mol Cell Biol 7:359–371

6.Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y (2003) Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 66:1124–1127

7.Matsumoto K, Akao Y, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y (2005) Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. Bioorg Med Chem 13:6064–6069

8.Itoh T, Ohguchi K, Iinuma M, Nozawa Y, Akao Y (2008) Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. Bioorg Med Chem 16:4500–4508

9.Akao Y, Nakagawa Y, Iinuma M, Nozawa Y (2008) Anti-cancer effects of xanthones from pericarps of mangosteen. Int J Mol Sci 9:355–370

10.Hung SH, Shen KH, Wu CH, Liu CL, Shin YW (2009) α-Mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway. J Agric Food Chem 57:1291–1298

11.Shibata M, Iinuma M, Morimoto J, Kurose H, Akamatsu K, Okuno Y, Akao Y, Otsuki Y (2011) α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Med 9:69

12.Krajarng A, Nakamura Y, Suksamrarn S, Watanapokasin W (2011) α-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway. J Agric Food Chem 59:5746–5754

13.Chao AC, Hsu YL, Liu CK, Kuo PL (2011) α-Mangostin, a dietary xanthone, induces autophagic cell death by activating the AMP-activated protein kinase pathway in glioblastoma cells. J Agric Food Chem 59:2086–2096

14.Ha DL, Hansen EP, Vang O, Duus F, Pham HD, Nguyen DLH (2009) Cytotoxic geranylated xanthones and O-alkylated derivatives of α-mangostin. Chem Pharm Bull 57:830–834

15.Sen KA, Sarkar KK, Majumder PC, Banerji N (1981) Minor xanthones of Garcinia mangostana. Phytochemistry 20:183–185

16.Ryu HW, Curtis-Long MJ, Jung S, Jin YM, Cho JK, Ryu YB, Lee WS, Park KH (2010) Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem 18:6258–6264

17.Sen KA, Sarkar KK, Majumder PC, Banerji N, Uusvuori R, Hase A (1980) A xanthone from Garcinia mangostana. Phytochemistry 19:2223–2225

18.Bennett JG, Harrison JL, Sia GL, Sim KY (1993) Triterpenoids, tocotrienols and xanthones from the bark of Cratoxylum cochinchinense. Phytochemistry 32:1245–1251

19.Sakai S, Katsura M, Takayama H, Aimi N, Chokethaworn N, Suttajit M (1993) The structure of garcinone E. Chem Pharm Bull 41:958–960

20.Nguyen DLH, Vo HT, Pham HD, Connolly JD, Harrison LJ (2003) Xanthones from the bark of Garcinia merguensis. Phytochemistry 63:467–470

21.Ee GC, Daud S, Taufiqyap YH, Ismail NH, Rahmani M (2006) Xanthones from Garcinia mangostana (Guttiferae). Nat Prod Res 20:1067–1073

22.Yu L, Zhao M, Yang B, Zhao Q, Jiang Y (2007) Phenolics from hull of Garcinia mangostana fruit and their antioxidant activities. Food Chem 104:176–181

23.Asai F, Tosa H, Tanaka T, Iinuma M (1995) A xanthine from pericarps of Garcinia mangostana. Phytochemistry 39:943–944

24.Chairungsrilerd N, Takeuchi K, Ohizumi Y, Nozoe S, Ohta T (1996) Mangostanol, a prenyl xanthone from Garcinia mangostana. Phytochemistry 43:1099–1102

发表评论

电子邮件地址不会被公开。 必填项已用*标注