When it comes to administering conventional pharmaceuticals simultaneously alongside a banaba supplement, there is no sizeable multicenter scale clinical trial to look at.
This is because this type of research has not been conducted with banaba supplements.
However, we do know that banaba extract supplements inhibit sulfation of the mood hormone dopamine.
Banaba has been known to inhibit the uptake of certain drugs through this mechanism potently. By 6.1%, in fact.
So what does all this mean? It means that taking a banaba extract supplement with oral medications that also use the OATP-B substrate may decrease their absorption, making these medications less effective.