Corosolic acid can be used as the novel plant-derived drug for prevention and treatment of obesity and type II diabetes drugs as well as the pharmaceutical raw materials of functional natural health food. It has currently become a hot product in the market. Currently the natural product has entered into market as a nutritional supplement in the United States and has been also subject to the Phase III clinical trials for the treatment of diabetes and will soon be approved by the FDA in the near future. Compared its efficacy in treating diabetes with that of the injections of insulin, it has various advantages such as significant oral administration effect, small toxic side effects, and being convenient for administration. Its efficacy is quite similar with injection of insulin.
The content of corosolic acid content in plants is generally low, even in the Lagerstroemia speciosa which has relative high content of Corosolic aicd. In the hot-wvater extracted concentrated extract of Lagerstroemia speciosa, the corosolic acid content is only about 0.01%. Even in the alocohol extract of Barnabas leaf, corosolic acid content is only about 1%. With years of research, Microherb has adopted advanced chromatographic separation technology for successfully isolation high purity (98%) corosolic acid, which can be further used for pharmacodynamic studies, clinical studies as well as toxicological experiment for prevention oadn treatment of obesity and type II diabetes.
The major efficacy of corosolic acid as follows:
- it can regulate the content of insulin and blood sugar with significant trend of weight loss in a slow process without the necessary for dieting. It therefore can be used for weight loss.
- this product has a significant hypoglycemic effect.
- it has a significant inhibitory effect on inflammation with the anti-inflammatory effect being stronger than commercially available anti-inflammatory drug, indomethacin.
- it has inhibitory effect on the proliferation of various kinds of tumors, and thus have wide prospects of applications in this field.
Physical and Chemical Properties
It is amorphous white powder (methanol), also known as plant insulin, 2α-hydroxy ursolic acid, and Barabbas extract or Lagerstroemia speciosa extract. It belongs to α-amyrin type or alkyl-type pentacyclic triterpenoids, and is soluble in petroleum ether, benzene, chloroform, pyridine and some other organic solvents, but insoluble in water; it is also soluble in hot ethanol, methanol. Under anhydrous conditions, when it is reacted with a strong acid (sulfuric acid, phosphoric acid, perchloric acid), the acid (TCA) or Lewis’s acid (zinc chloride, aluminum chloride, antimony trichloride), there will be colorimetric reaction or fluorescence.