banaba leaf extract corosolic acid usage

Corosolic acid has properties that help stem diabetes, kill cancer cells, reduce inflammation and blood pressure, and regulate fat metabolism. Effect of corosolic acid on postchallenge plasma glucose levels. Corosolic acid (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, corosolic acid did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally Corosolic acid significantly inhibited cell viability in both a dose- and a time-dependent manner. Corosolic acid treatment induced S cell-cycle arrest and caused apoptotic death in HeLa cells. We found that Corosolic acid increased in Bax/Bcl-2 ratios by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. Moreover, Corosolic acid treatment triggered the activation of caspase-8, -9 and -3 in HeLa cells. All these results indicate that Corosolic acid-induced apoptosis is associated with the activation of caspases via a mitochondrial pathway. Taken together, we believe that Corosolic acid could have strong potentials for clinical application in treating human cervix adenocarcinoma and improving cancer Chemotherapy.