Neuropathy always involves damage to the small nerve fibers. The present study was designed to investigate the effects of Banaba leaf extract on chronic constriction injury (CCI) induced neuropathic pain in experimental animals. Methods: Wistar rats (200–250g) of either sex were used in the present study, they were divided into five groups – each containing six rats. Neuropathic pain was induced by chronic constriction injury (CCI) in rats. Pain was assessed by mechanical hyperalgesia, cold allodynia, and thermal hyperalgesia. Markers of oxidative stress, such as Lipid peroxidation and reduced glutathione were evaluated in sciatic nerve preparation. Banaba leaf extracts (50 and 100 mg/kg/p.o) were administered to the animals daily. Results: Treatment with Banaba extract showed a significant and dose dependent increase in pain threshold in all the models. It also displayed significant reduction in Lipid peroxidation and an increase in reduced glutathione contents. Conclusion: The present results showed the neuroprotective and antioxidant effects of Banaba leaf extract.