HPLC determination of corosolic acid in Corni Fructus

To establish an HPLC method for determination of corosolic acid in Corni Fructus.Methods:A Inertsil ODS-3(150 mm×4.6 mm,5 μm) column was adopted;The mobile phase consisted of methanol-distilled water-phosphoric acid(82∶ 18∶ 0.2) at a flow rate of 1.0 mL·min-1;The detection wavelenth was 205 nm,and the column temperature was 30 ℃.Results:The standard curves of corosolic acid shows a good linearity in the concentration range of 59.86-598.6 μg·mL-1,and the average recovery(n=6) was 98.7% with RSD of 1.0%.Conclusion:This method is simple,repeatable,and has good resolution and high selectivity.It can be used for the determination of corosolic acid in Corni Fructus.

HPLC determination of corosolic acid in Corni Fructus

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