Preventive Effect of Corosolic Acid on Lipid Profile Against Carbon Tetrachloride-Induced Hepatotoxic Rats

The present study was designed to investigate the hepatoprotective activity of corosolic acid in CCU-induced hepatotoxic male albino rats and included an assessment of the antihyperlipidemic properties. Liver necrosis was induced by intraperitoneal injection of CCU (1.25 mL/kg b.wt.). Hyperlipidemic agents, such as lipid peroxidation, lipid profile and liver function markers were assessed. The activities of the hepatic marker enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (GGT) were increased significantly in CCI4-treated animals. In the serum, increased levels of very low density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) and decreased high density lipoprotein cholesterol (HDL-C) were observed. Further, an increase in the levels of total cholesterol (TC), phospholipids (PL), triglycerides (TG) and free fatty acids (FFA) in serum and liver were observed in hepatotoxic rats, whereas these hepatic marker enzymes and lipid profiles were significantly protected

Preventive Effect of Corosolic Acid on Lipid Profile Against Carbon Tetrachloride-Induced Hepatotoxic Rats
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