Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of CRA on the development of obesity and hepatic steatosis in KK-Ay mice, a genetically obese mouse model. Six-week-old KK-Ay mice were fed a high fat diet for 9 weeks with or without 0.023% CRA. Nine-week CRA treatment resulted in 10% lower body weight and 15% lower total fat (visceral plus subcutaneous fat) mass than in control mice. CRA treatment reduced fasting plasma levels of glucose, insulin, and triglyceride by 23%, 41%, and 22%, respectively. The improved insulin sensitivity in CRA-treated mice may be due on part to the increased plasma adiponectin and white adipose tissue (WAT) AdipoR1 levels. In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR)a in liver and PPAR gamma in WAT
Staherb Natural Ingredients Co., Ltd main product include banaba leaf extract Corosolic acid (1-98%),Dihydromyricetin (1-98%), Euccomia Bark Extract (5-95%),
Amygdalin (50-98%),Ursolic acid (25-98%) ,myricetin(10%-98%),magnolia bark extract,rosmary leaf extract ,macleaya cordata extract ect.
Banaba leaf extract corosolic acid contact firstname.lastname@example.org