Corosolic Acid May Becomes the Future Anti-diabetic Drug

Banaba leaf extract (or corosolic acid) is typically found in supplements that help support healthy blood sugar levels and is claimed to stimulate glucose uptake and heighten insulin sensitivity.

Rats fed with 1% corosolic acid  exhibited significantly reduced blood glucose after 90 minutes [1]. Same formulation also exhibited significant and dose-dependent reduction in blood glucose (30% decrease after 2 weeks) over the range of 16-48 mg per day in 10 subjects with type II diabetes [2]. A study in KK-Ay mice reported dose-dependent reduction in blood glucose levels 4 h after a single oral dose (2 mg/kg) which supported the hypotesis that corosolic acid improves glucose metabolism by reducing insulin resistance [3]. A 12% decrease in fasting blood glucose was reported in 12 non-diabetic subjects who were given 10 mg of corosolic acid (as banaba extract standardized to 18% corosolic acid) for 2 weeks [4]. In an unpublished study by Xu (mentioned in a review by Stohs et al. [5]) subjects received soft gel caps containing 10 mg of corosolic acid. Both fasting and 2h post-prandial blood glucose levels decreased by 10% compared to placebo group [5]. In Fukushima et al. study [6] 31 subjects were given 10 mg corosolic acid (99% pure) or placebo 5 minutes after 75 g of glucose tolerance test. It has been reported that corosolic acid reduced blood glucose levels from 60 to 120 minutes, with highest difference at 90 minutes.

Corosolic Acid May Becomes the Future Anti-diabetic Drug
corosolic acid

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